17 dic 2011

Dr. David Alcantara

PROFESSIONAL /RESEARCH EXPERIENCE 

08/2010-present   President of SACSIS

03/2013-03/2015   Senior Marie Curie Research Fellow position at Andalusian Center for Nanomedicine (Bionand): Magnetic PCR project

 01/2012-01/2013   Marie Curie Fellow position at Institute of Nanoscience of Aragon. University of Zaragoza.

01/2010-12/2011 Marie Curie Fellow position at Center for Nuclear Medicine and Molecular Imaging Research. Harvard Medical School

05/2009-12/2009   Fulbright Postdoctoral position at Center for Molecular Imaging Research. Harvard Medical School

10/2008-4/2009   CNRS Postdoctoral position at Laboratoire de Résonance Magnétique des Systémes Biologiques (RMSB), Université Victor Segalen Bordeaux II–CNRS
PUBLICATIONS

  1.  D. Alcantara, S Lopez, ML García-Martín, D. Pozo "Iron Oxide Nanoparticles as magnetic relaxation switching (MRSw) sensors: Current applications in Nanomedicine "Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 12, 5, 1252-1262
  2. D. Alcantara "A new type of journal on Nanotechnology"All Res. J. Nano, 2015, 1, 1, 1-2
  3. D. Alcantara "Thank you to reviewers of negative results in 2015"All Res. J. Biol, 2015, 6, 3, 30
  4. D. Alcantara, Manuel Pernia Leal, Irene Bocanegra, ML García-Martín "Molecular imaging of breast cancer: present and future directions" Frontiers in Chemistry, 2014, 2, 112
  5. U. Mahmood, P. Heidari, P. Habibolahi, H.Cho, D. Alcantara, L. Josephson “Fluorescent nanoparticle imaging allows non-invasive evaluation of immune cell modulation in esophageal dysplasia” Molecular Imaging, 2014, 13 (3) 1-11
  6. David Alcantara, Elia Grueso, Paula M Castillo, Rafael Prado-Gotor "AuNP's-DNA non covalent interactions: Improve of some studies and new avenues of research from negative results" The All Results Journals:Chem, 2013, 4, 1, 1-9
  7. Nuria O Nuñez, Sara Rivera, David Alcantara, Jesus M de la Fuente, Jorge García-Sevillano, Manuel Ocaña "Surface modified Eu:GdVO4 nanocrystals for optical and MRI imaging" Dalton Transactions, 2013, 42 (30), 10725-10734; DOI: 10.1039/C3DT50676B
  8. Hoonsung Cho, David Alcantara, Rahul A. Sheth, Howard H. Chen, Peng Huang, Sean B. Andersson, David E. Sosnovik, Umar Mahmood, and Lee Josephson. "High Valency DNA Binding Fluorochrome-Magnetic Nanoparticles" ACS Nano, 2013, Mar 26; 7(3):2032-41.
  9.  Rodriguez-Liviano S, Becerro AI, Alcántara D, Grazú V, de la Fuente JM, Ocaña M. “Synthesis and properties of multifunctional tetragonal Eu:GdPO4 nanocubes for optical and magnetic resonance imaging applications” Inorg. Chem, 2013, 52(2):647-54
  10. David Alcantara, "A closer look" All Res. J. Biol, 2012, 3, i
  11. David Alcantara, Yanyan Guo, Hushan Yuan, Craig J. Goergen, Howard Chen, Hoonsung Cho, David E. Sosnovik, Josephson, L. “Fluorochrome-Functionalized Magnetic Nanoparticles for High-Sensitivity Monitoring of the Polymerase Chain Reaction by Magnetic Resonance”, Angew. Chem. Int. Ed., 2012, 51, 6904-7
  12. David Alcantara, Javier Reguera. " Editorial", All Res. J. Phys, 2011, 1, 1-3
  13. Chen, S., Alcantara, D., Josephson, L. “A Magnetofluorescent Nanoparticle for Cell Labeling by Covalently Linking the Drugs Protamine and Feraheme”, J Nanosci Nanotechnol., 2011, 11 (4), 3058-64
  14. David Alcantara, Rafael Prado Gotor. " Editorial", All Res. J. Chem, 2010, 1, 1-3.
  15. David Alcantara, Joe Blois, Carlos Ceacero, "Editorial", All Res. J. Biol, 2010, 1, 1-3.
  16. Larrosa, Mar; Tomé-Carneiro, Joao; Yañez-Gascón, María; Alcántara, David; Selma, Maria; Beltrán, David; García-Conesa, María-Teresa; Urbán, Cristina; Lucas, Ricardo; Tomas-Barberan, Francisco; Morales, Juan; Espín, Juan Carlos. "Preventive Oral Treatment with Resveratrol Pro-drugs Drastically Reduce Colon Inflammation in Rodents", Journal of Medicinal Chemistry, 2010, 53 (20), 7365-73.
  17. Medina I, Alcántara D, González MJ, Torres P, Lucas R, Roque J, Plou FJ, Morales JC. “Antioxidant activity of resveratrol in several fish lipid matrices: effect of acylation and glucosylation” J Agric Food Chem. 2010 Sep 8;58(17):9778-86.
  18. Ricardo Lucas, Francisco Comelles, David Alcántara, Olivia S. Maldonado, Melanie Curcuroze, Jose Luis Parra and Juan Carlos Morales. “Surface-active properties of lipophilic antioxidants tyrosol and hydroxytyrosol fatty acid esters: a potential explanation for the nonlinear hypothesis of the antioxidant activity in oil-in-water emulsions”, J Agric Food Chem. 2010 Jul 14;58(13):8021-6
  19. I. Medina, S. Lois, D. Alcántara, R. Lucas, J. C. Morales “Effect of lipophilization of hydroxytyrosol on its antioxidant activity in fish oils and fish oil-in-water emulsions” J Agr Food Chem , 2009, 57 (20), 9773–9779
  20. Lucas, Ricardo; Alcántara, David; Morales, Juan C. “A concise synthesis of glucuronide metabolites of biologically relevant dietary bioactive phenolics: hydroxytyrosol, resveratrol and urolithin-B”  J Carb Res, 2009, 344, 1340-1346  
  21. David Alcantara, Jesus M. de la Fuente. “Agentes de contraste positivos en imagen por Resonancia Magnética para la diagnosis del cáncer”, revista eSalud, 2009, 5, 17.
  22. D. Alcántara, J. M. de la Fuente,  M. Marradi, M. Garcia-Martin,  S. Cerdan, and S. Penadés. “Paramagnetic Gold Glyconanoparticles as New Contrast Agents for Brain Tumour Imaging: the Sugars Control Relaxivities and in vivo Selectivity". Chem Comm, 2009, 26, 3922-4; DOI: 10.1039/b900957d
  23. Martina Fuss, David Alcantara, Jesús M. de la Fuente, Pedro M. Enríquez-Navas, Jesús Angulo, Soledad Penadés, Mónica Luna* and Fernando Briones.  “3D multilayer self-assembling of maltose neoglycoconjugate disulfides on hydrophobic graphite”, J. Phys. Chem. B, 2008, 112 (37), 11595–11600.   
  24. Fuss, Martina; Alcántara, David; De La Fuente, Jesús; Luna, Mónica; Briones, Fernando; Penadés, Soledad. “Supramolecular self-assembled arrangements of maltose glyconanoparticles”, Langmuir, 2008, 24, 5124-5128.
  25. Soledad Penadés, J. M. de la Fuente, A. G. Barrientos, Caroline Clavel, O. Martínez-ávila and D. Alcántara. “Multifunctional Glyconanoparticles for application in biology and biomedicine” in  Nanomaterials for Application in Medicine and Biology, 2008, pp 93-101.
  26. J.M. de la Fuente, D.Alcantara, S.Penadés “Cell response against magnetic glyconanoparticles: Does the carbohydrate matter?”, IEEE Trans. in Nanobioscience, 2007, 6, 275-281.
  27. E. Grueso, D. Alcantara, J. Martinez, M. Mancera, S. Penades, F. Sanchez and R. Pradogotor “A kinetic approach for the study of non-covalent interaction between [Ru(NH3)5pz]2+ and gold nanoparticles” J.Chem.Phys.A, 2007, 111, 9769-9774.  
  28. de la Fuente, J.M,  Alcántara D,  Eaton, P,  Crespo, P,  Rojas TC, Fernandez A ,Hernando A, Penades S. “Gold and Gold-iron Magnetic Glyconanoparticles: Synthesis, characterization and magnetic properties”;  J.Chem.Phys.B, 2006, 110, 13021-13028
  29. P.Crespo, M.A.Garcia, E.Fernandez, M.Multigner, D.Alcántara, J.M. de la Fuente, S. Penadés, A.Hernando. “Fe impurities weaken the ferromagnetic behaviour in Au Nanoparticles”, Phys.Rev.Lett., 2006, 97, 17, 177203.  
  30. de la Fuente, J.M.; Alcántara D.; Barrientos, A.G.; García, M.L.; Cerdán S.; Penadés, S. “Glyconanoparticles: New Nanomaterials for Glycoscience Studies”;  Glycoconj.J.,2005,  22, 262-263
  31. F.Garcia Sanchez, A.Navas Diaz, A.F.Gonzalez Diaz, M.C.Torrijas, D.Alcántara, S.A.Eremin “Development of homogeneous phase-modulation fluoroimmunoassay for 2,4-dicholorophenoxyacetic acid”; Analitica Chimica Acta, 1999, 395, 133-142


PATENT PRESENTATIONS


  1. J.C. Morales , F. Comelles, JL. Parra Juez, D. Alcántara, R. Lucas, O. Sanchez, M. Curcuroze. “Fenoles lipofilicos como surfactants antioxidantes” Patent number: PCT/ES2010/070857, 2010.
  2. J. C. Morales , J.C. Espin de Gea, I Medina Mendez, M. Larrosa, D. Alcántara, M.J. Yanez ,F. A. Tomas-Barberam,M.J. Gonzalez, M.S. Lois, R. Lucas, M.V. Selma, J. Tome. “Preparacion del piceido-butirato y piceido-octanoato y su uso en enfermedades de origen inflamatorio.” Patent number: PCT/ES2010/070826,  2009.
  3. David Alcantara, Lee Josephson. " Nanocompositions for monitoring Polymerase Chain Reactions" Patent number: WO/2012/154555; International Application No.: PCT/US2012/036505. 2012

BOOKS / BOOK CHAPTERS



PRIZES
  1. Foundation Felix Delgado Bocos, 2012,  "Best innovative approach in biomedical science" see link
  2. Junta de Andalucia, 2009, price for best entrepreneurship, The All Results Journals
  3. Finalist in “Young Entrepreneur” Prize, Alcala de Guadaira City Council (Spain), 2009, Project: The All Results Journals  
  4. Bancaja  Prize 2008 Best Young Entrepreneur, Valencia (Spain), Project: The All Results Journals.
  5. Best poster performance, Conference: Trends in NanoTechnology, September 2005, Oviedo (Spain)
OTHER ACHIEVEMENTS

2008-present: Editor in Chief, The All Results Journals
2010-present: President of the Society for the Improvement of Science

CONFERENCES AND COMMUNICATIONS
 
  1. “Glyconanotechnology: A New Methodology to create Nanoparticles with Applications in Biotechnology and Material Science” David Alcántara, Peter Eaton,Africa G.Barrientos, Jesus M.de la Fuente, Soledad Penadés,. VIII Congreso Nacional de Materiales, 2004, Valencia . Poster 
  2. “Magnetic glyconanoparticles:preparations, characterization and potential applications” David Alcántara, Africa G.Barrientos, Jesús M.de la Fuente, Soledad Penadés. 22nd International Carbohydrate Symposium, Julio 2004, Glasgow (U.K). Poster 
  3. “Magnetic glyconanoparticles:preparation, characterization and MRI applications” David Alcántara,Jesús M.de la Fuente,M.L.García, Sebastián Cerdán and Soledad Penadés. NanoSpain, May 2005, Barcelona. Poster 
  4. Magnetic glyconanoparticles:preparation, characterization and Magnetic Resonance Imaging applications” David Alcántara,Jesús M.de la Fuente,M.L.García, Sebastián Cerdán, Soledad Penadés. Trends in NanoTechnology, September 2005, Oviedo. Poster. 
  5. “Glyconanoparticles: New Materials for Glycoscience Studies” David Alcántara, Africa G.Barrientos, Jesús M.de la Fuente, M.L.García, Sebastián Cerdán, Soledad Penadés. Glyco XVIII: International Symposium on Glycoconjugates, Florencia (Italy), 2005. Poster 
  6. “Glyconanoparticles: a New materials for glyconsciences studies” Jesus M. de la Fuente, David Alcántara, Africa G.Barrientos,M.L.García, Sebastián Cerdán, Soledad Penadés. Simposio Severo Ochoa: " Ochoa 100 años : Mirando al futuro", Madrid, November 2005. Poster 
  7. “Water Soluble Glyconanoparticles: synthesis, Characterization, Cell Response and Applications as Contrast Agents for MRI”. de la Fuente, J.M.; Alcántara D.; García, M.L.; Crespo, P.; Hernando, A.; Cerdán, S.; Penadés, S. NanoSpain2006, April 2006, Pamplona. Oral 
  8. “Gold and Gold-Iron Water Soluble Glyconanoparticles: Tools for the emerging Nanomedicine” David Alcántara, Jesus M de la Fuente, Patricia Crespo, Antonio Hernando, M.L.García, Sebastián Cerdán, Soledad Penadés. NanobioEurope2006 ,Grenoble (France). Poster. 
  9. “Water Soluble Glyconanoparticles: Synthesis, Characterization, Cell Response and Applications as contrast Agents for MRI.” de la Fuente, J.M.; Alcántara, D.; García, M.L; Crespo, P.; Hernando, A.; Cerdán, S.; Penadés, S., ICN+T06, Basil (Swizerland), July 2006. Poster. 
  10. “Glyconanoparticle-DNA interactions: an AFM and TEM study” Peter Eaton, Jesus M de la Fuente, Africa G. Barrientos, David Alcantara, Raul V. Duran, Cristina T. Rojo and Soledad Penades. ICN+T06, Basil (Swizerland), July 2006. Poster. 
  11. “Water Soluble Magnetic Glyconanoparticles: Synthesis, Characterization, Cell Response and Applications as contrast Agents for MRI.” David Alcántara, Jesus M de la Fuete and Soledad Penadés, S., VIII Jornadas de Carbohidratos, Alcalá de Henares (Madrid), September 2006. Poster. 
  12. Water Soluble Magnetic Glyconanoparticles: Synthesis, Characterization, Cell Response and Applications as contrast Agents for MRI.” Jesús M de la Fuente. David Alcántara, and Soledad Penades; III Nanospain Workshop, Pamplona (Spain), March 2006. Poster. 
  13. “Glyconanotechnology: A method for the preparation of biofuntional nanoparticles with application in nanomedicine” M. Marradi, O. Martinez-Ávila, D. Alcántara, J. M. de la Fuente and S. Penadés. TNT2007, San Sebastián (Spain), September 2007. Oral. 
  14. “Synthesis of novel resveratrol and hydroxytirosol derivatives: evaluation as food antioxidants” David Alcantara, José Manuel Gallardo, Isabel Medina and Juan Carlos Morales. XXII Bienal de Química Orgánica. Tarragona (Spain), June 2008. Oral 
  15. “Identification of Microorganisms with Magnetic Relaxation Switches” David Alcantara and Lee Josephson. MRS 2010 Fall Meeting, Boston (USA). Oral. 
  16. “Nanoparticles for Cell Labeling: Covalent Attachment of the Drug Protamine to FDA Approved Nanoparticles” Suelin Chen, David Alcantara, Ralph Weissleder and Lee Josephson. MRS 2010 Fall Meeting, Boston (USA). Poster. 
  17. “A sensitive MR method for DNA detection with magnetic nanoparticles” D. Alcantara, Y. Guo, H. Yuan, L. Josephson, BioNanoTech Conference & Expo, June 2011, Boston (USA). Poster 
  18. “PCR monitoring by MR: An ultrasensitive method for DNA detection with magnetic nanoparticles”, D. Alcantara, Y. Guo, H. Yua, L. Josephson. Nanax5 Conference, May 2012, Malaga (Spain). Poster. 
  19. “Errores a evitar para obtener una Marie Curie” David Alcantara. VII Congreso Internacional Federación Española de Biotecnólogos, July 2013, Seville (Spain). Oral 
  20. “Magnetic fluorochrome nanoparticles for an ultrasensitive DNA detection in biological systems” David Alcantara, Hoonsung Cho, Yanyan Guo, Lee Josephson, Maria L. Garcia-Martin. XXXIV Reunión Bienal de la Real Sociedad Española de Química, September 2013, Santander (Spain). Oral 
  21. “Ultrasensitive DNA detection in biological systems using Magnetic fluorochrome nanoparticles” David Alcantara, Hoonsung Cho, Yanyan Guo, Lee Josephson, Maria L. Garcia-Martin. Trends in Nanotechnology, September 2013, Seville (Spain). Oral 
  22. “Magnetic Switches as ultrasensitive DNA detection tool for Nanomedicine” David Alcantara, Hoonsung Cho, Lee Josephson, Maria L. Garcia-Martin. Materials Today Virtual Conference 2013, October 2013. Poster
  23.